Catalytic features of the botulinum neurotoxin A light chain revealed by high resolution structure of an inhibitory peptide complex.

@article{Silvaggi2008CatalyticFO,
  title={Catalytic features of the botulinum neurotoxin A light chain revealed by high resolution structure of an inhibitory peptide complex.},
  author={Nicholas R Silvaggi and David Wilson and Saul Tzipori and Karen N. Allen},
  journal={Biochemistry},
  year={2008},
  volume={47 21},
  pages={5736-45}
}
The Clostridium botulinum neurotoxin serotype A light chain (BoNT/A-LC) is a Zn(II)-dependent metalloprotease that blocks the release of acetylcholine at the neuromuscular junction by cleaving SNAP-25, one of the SNARE proteins required for exocytosis. Because of the potential for use of the toxin in bioterrorism and the increasingly widespread application of the toxin in the medical field, there is significant interest in the development of small-molecule inhibitors of the metalloprotease… CONTINUE READING
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