Catalytic enantioselective synthesis of key intermediates for triazole antifungal agents.

@article{Suzuki2005CatalyticES,
  title={Catalytic enantioselective synthesis of key intermediates for triazole antifungal agents.},
  author={Masato Suzuki and Nobuki Kato and Motomu Kanai and Masakatsu Shibasaki},
  journal={Organic letters},
  year={2005},
  volume={7 13},
  pages={
          2527-30
        }
}
[reaction: see text] A short-step synthesis of versatile chiral building blocks for triazole antifungal agents such as ZD0870 and Sch45450 was developed via catalytic enantioselective cyanosilylation of electron-deficient ketones as the key step. High enantioselectivity was produced using a catalyst prepared from Gd(HMDS)(3) and ligand 5 in a 2:3 ratio. This new catalyst preparation method was superior to the previous method using Gd(O(i)Pr)(3) as a metal source. A rationale for the difference… 
34 Citations
An enantioselective synthesis of the key intermediate for triazole antifungal agents; application to the catalytic asymmetric synthesis of efinaconazole (Jublia).
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