Catalytic dehydrogenative N-((triisopropylsilyl)oxy)carbonyl (Tsoc) protection of amines using iPr3SiH and CO2.

Abstract

A versatile method has been found to catalyze the dehydrogenative N-((triisopropylsilyl)oxy)carbonyl (Tsoc) protection of amines using Pd/C, volatile iPr3SiH and CO2 gas without the liberation of any salts. A simple filtration/evaporation process facilitates the easy isolation of the product, thereby enhancing the utility of Tsoc as an amine-protecting group in organic synthesis.

DOI: 10.1039/c5cc04594k

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Cite this paper

@article{Tanaka2015CatalyticDN, title={Catalytic dehydrogenative N-((triisopropylsilyl)oxy)carbonyl (Tsoc) protection of amines using iPr3SiH and CO2.}, author={Sachiko Tanaka and Takehira Yamamura and Shota Nakane and Mineaki Kitamura}, journal={Chemical communications}, year={2015}, volume={51 66}, pages={13110-2} }