Catalytic asymmetric construction of spirocyclopentaneoxindoles by a combined Ru-catalyzed cross-metathesis/double Michael addition sequence.

@article{Li2011CatalyticAC,
  title={Catalytic asymmetric construction of spirocyclopentaneoxindoles by a combined Ru-catalyzed cross-metathesis/double Michael addition sequence.},
  author={Ying-Mei Li and Xiang Li and Fang-Zhi Peng and Ze-Qian Li and Shou-Tao Wu and Zhong-wen Sun and Hong-bin Zhang and Zhihui Shao},
  journal={Organic letters},
  year={2011},
  volume={13 23},
  pages={6200-3}
}
Biologically important and synthetically challenging spirocyclopentaneoxindoles with four contiguous stereocenters including one spiroquaternary stereocenter have been constructed in good yields (72-87%) with excellent diastereoselectivity (16:1→30:1 dr) and enantioselectivity (93→99% ee) by a combined Ru-catalyzed cross-metathesis/organocatalyzed asymmetric double-Michael addition sequence.