Catalytic asymmetric acyl halide-aldehyde cyclocondensation reactions of substituted ketenes.

@article{Nelson2004CatalyticAA,
  title={Catalytic asymmetric acyl halide-aldehyde cyclocondensation reactions of substituted ketenes.},
  author={Scott G Nelson and Cheng Zhu and Xiaoqiang Shen},
  journal={Journal of the American Chemical Society},
  year={2004},
  volume={126 1},
  pages={14-5}
}
Catalytic asymmetric acyl halide-aldehyde cyclocondensation (AAC) reactions of alkyl-substituted ketenes with structurally diverse aldehydes provide cis-disubstituted beta-lactones with high enantioselectivity. The AAC reactions utilize a novel Al(III)-triamine catalyst in which the metal's dynamic coordination geometry leads to a highly selective catalyst complex. These AAC reactions represent a functional solution to highly enantioselective substituted ester enolate aldol additions.