Catalytic antibodies and their applications.

  title={Catalytic antibodies and their applications.},
  author={Carl Veith Hanson and Yasuhiro Nishiyama and Sudhir Paul},
  journal={Current opinion in biotechnology},
  volume={16 6},
Catalytic antibodies (CAbs) occur naturally in healthy individuals where they may form part of the innate immune system, but are preferentially found in those with autoimmune disease. CAbs can also be artificially engineered or elicited by immunizations. Their mechanisms of action include nucleophilic catalysis, induction of conformational strain, coordination with metal ions, and stabilization of transition states. Recent applications of CAbs with clinical significance include the conversion… CONTINUE READING


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