Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase.

@article{Huang1993CatalyticAR,
  title={Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase.},
  author={Clark Huang and Long-sen Chang and Mary E Anderson and Alton Meister},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 26},
  pages={19675-80}
}
gamma-Glutamylcysteine synthetase (rat kidney), which catalyzes the first step of GSH synthesis, can be dissociated into subunits (M(r) 73,000 and 27,700) by native gel electrophoresis after treatment with dithiothreitol (DTT); the heavy subunit, which exhibits catalytic activity and feedback inhibition by GSH (Seelig, G. F., Simondsen, R. P., and Meister, A. (1984) J. Biol. Chem. 259, 9345-9347), was cloned and sequenced (Yan, N., and Meister, A. (1990) J. Biol. Chem. 265, 1588-1593). Here… CONTINUE READING

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