Catalytic activity and expression of two flavin-containing monooxygenases from Drosophila melanogaster.

@article{Scharf2004CatalyticAA,
  title={Catalytic activity and expression of two flavin-containing monooxygenases from Drosophila melanogaster.},
  author={Michael E. Scharf and Dancia W. Scharf and Gary W. Bennett and Barry R. Pittendrigh},
  journal={Archives of insect biochemistry and physiology},
  year={2004},
  volume={57 1},
  pages={28-39}
}
Two flavin-containing monooxygenase genes occur in the Drosophila genome (named DmFMO-1 and DmFMO-2). Differences exist between these two FMOs in: (1) genomic DNA architecture and predicted post-translational modifications; (2) recombinant protein solubility, activity, and absorbance spectra; and (3) subcellular distribution and developmental transcription/translation profiles in wildtype flies. Characteristic FAD absorbance spectra and strong catalytic competence in methimazole sulfoxidation… CONTINUE READING