Catalytic Radical Trifluoromethylalkynylation of Unactivated Alkenes.

  title={Catalytic Radical Trifluoromethylalkynylation of Unactivated Alkenes.},
  author={Shaofang Zhou and Tao Song and He Chen and Zhonglin Liu and Haigen Shen and Chaozhong Li},
  journal={Organic letters},
  volume={19 3},
The trifluoromethylalkynylation of unactivated alkenes with alkynyl sulfones and Togni's reagent was developed. The reaction was catalyzed by 2,4,6-trimethylpyridine, leading to various β-trifluoromethylated alkynes under metal-free conditions with a broad substrate scope and wide functional group compatibility. A mechanism involving catalytic nonchain radical processes is proposed. 
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