Catalytic Hydration of Alkynes and Its Application in Synthesis

@article{Hintermann2007CatalyticHO,
  title={Catalytic Hydration of Alkynes and Its Application in Synthesis},
  author={Lukas Hintermann and Aur{\'e}lie Labonne},
  journal={Synthesis},
  year={2007},
  volume={2007},
  pages={1121-1150}
}
  • Lukas Hintermann, Aurélie Labonne
  • Published 2007
  • Chemistry
  • Synthesis
  • The catalytic addition of water to alkynes (hydration) generates valuable carbonyl compounds from unsaturated hydrocarbon precursors. Traditional mercury(II) catalysts hydrate terminal alkynes with Markovnikov selectivity to methyl ketones. Much research has been devoted to finding catalysts based on less toxic metals, the most promising being gold(I), gold(III), platinum(II), and palladium(II). Catalytic anti-Markovnikov hydration of terminal alkynes to aldehydes has been realized in an… CONTINUE READING
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