Catalysts for the self-polymerization of adenosine cyclic 2′,3′-phosphate

@article{Verlander2005CatalystsFT,
  title={Catalysts for the self-polymerization of adenosine cyclic 2′,3′-phosphate},
  author={M. Verlander and R. Lohrmann and L. Orgel},
  journal={Journal of Molecular Evolution},
  year={2005},
  volume={2},
  pages={303-316}
}
SummaryWhen adenosine cyclic 2′,3′-phosphate is evaporated from solution in the presence of simple catalysts such as aliphatic diamines at alkaline pH, and maintained in a dry state at moderate temperatures (25-85°C), self-polymerization to give oligonucleotides of chainlength up to at least 6 is observed. The products contain an excess of [3′→5′]-linkages over [2′→5′]-linkages. The effects of different catalysts and reaction conditions on the efficiency of the reaction are described. The… Expand
View on Springer
ncbi.nlm.nih.gov
89 Citations
Highly Influential Citations
2
Background Citations
23
Methods Citations
2
Results Citations
1

Figures, Tables, and Topics from this paper

89 Citations

Citation Type

Citation Type

Geometry of the dry-state oligomerization of 2′,3′-cyclic phosphates
  • 9
Specific effect of magnesium ion on 2′, 3′-cyclic amp synthesis from adenosine and trimeta phosphate in aqueous solution
  • 26
May Cyclic Nucleotides Be a Source for Abiotic RNA Synthesis?
  • 8
The prebiotic synthesis of deoxythymidine oligonucleotides
  • 13
Nonenzymatic template-dependent ligation of 2′,3′-cyclic phosphate-containing oligonucleotides catalyzed by metal ions
  • 7
The nonenzymatic template-directed ligation of oligonucleotides
  • 13
  • PDF
Non-Enzymatic Oligomerization of 3’, 5’ Cyclic AMP
  • 8
  • PDF
From the one-carbon amide formamide to RNA all the steps are prebiotically possible.
  • 25
Nonenzymatic Oligomerization of 3′,5′‐Cyclic CMP Induced by Proton and UV Irradiation Hints at a Nonfastidious Origin of RNA
  • 8
  • PDF
Reaction of Cytidine Nucleotides with Cyanoacetylene: Support for the Intermediacy of Nucleoside‐2′,3′‐cyclic Phosphates in the Prebiotic Synthesis of RNA
  • 15
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 10 REFERENCES
Catalysts for the polymerization of adenosine cyclic 2',3'-phosphate on a poly (U) template.
  • 79
Further studies of urea-catalyzed phosphorylation reactions
  • 50
Condensation of mononucleotides by imidazole
  • 16
Urea-Inorganic Phosphate Mixtures as Prebiotic Phosphorylating Agents
  • 168
Prebiotic Formation of Cytidine Nucleotides
  • 90
The mechanism of action of ribonuclease.
  • 113
  • PDF
Biochim. biophys
  • Czech. Chem. Comm. 33,
  • 1968
Thermic phosphorylations. IV. Preferential formation of a natural internucleotide bond in oligonucleotides formed by heating uridine 2'(3')-phosphate with uridine
  • 9
Thermic phosphorylations. II. The formation of 3'→5' and 2'→5' dinucleoside phosphates through a reaction of uridine and 6-azauridine with inorganic phosphate
  • 6
Carbodiimides. VIII.1 Observations on the Reactions of Carbodiimides with Acids and Some New Applications in the Synthesis of Phosphoric Acid Esters
  • 182