Catalysts for the self-polymerization of adenosine cyclic 2′,3′-phosphate

@article{Verlander2005CatalystsFT,
  title={Catalysts for the self-polymerization of adenosine cyclic 2′,3′-phosphate},
  author={M. Verlander and R. Lohrmann and L. Orgel},
  journal={Journal of Molecular Evolution},
  year={2005},
  volume={2},
  pages={303-316}
}
SummaryWhen adenosine cyclic 2′,3′-phosphate is evaporated from solution in the presence of simple catalysts such as aliphatic diamines at alkaline pH, and maintained in a dry state at moderate temperatures (25-85°C), self-polymerization to give oligonucleotides of chainlength up to at least 6 is observed. The products contain an excess of [3′→5′]-linkages over [2′→5′]-linkages. The effects of different catalysts and reaction conditions on the efficiency of the reaction are described. The… Expand
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