Catalysis of the photo-Fries reaction: antibody-mediated stabilization of high energy states.

Abstract

A conformationally constrained hapten is presented that is capable of catalyzing the first antibody-mediated photo-Fries rearrangement. In this reaction, absorption of light energy by a diphenyl ether substrate results in homolytic C-O bond cleavage followed by recombination to yield biphenyl-derived products. The most proficient antibody studied converts 4… (More)

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@article{Dickerson2003CatalysisOT, title={Catalysis of the photo-Fries reaction: antibody-mediated stabilization of high energy states.}, author={Tobin J. Dickerson and Martin R Tremblay and Timothy Z Hoffman and D. Ruiz and Kim D Janda}, journal={Journal of the American Chemical Society}, year={2003}, volume={125 50}, pages={15395-401} }