Catalysis of disulfide bond formation and isomerization in the Escherichia coli periplasm.

@article{Nakamoto2004CatalysisOD,
  title={Catalysis of disulfide bond formation and isomerization in the Escherichia coli periplasm.},
  author={Hitoshi Nakamoto and James C. A. Bardwell},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1694 1-3},
  pages={111-9}
}
Disulfide bond formation is a catalyzed process in vivo. In prokaryotes, the oxidation of cysteine pairs is achieved by the transfer of disulfides from the highly oxidizing DsbA/DsbB catalytic machinery to substrate proteins. The oxidizing power utilized by this system comes from the membrane-embedded electron transport system, which utilizes molecular oxygen as a final oxidant. Proofreading of disulfide bond formation is performed by the DsbC/DsbD system, which has the ability to rearrange non… CONTINUE READING