Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8.

@article{Hotta2000CatalysisOD,
  title={Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8.},
  author={Kinya Hotta and Hans -Walter Lange and Dean J. Tantillo and Kendall N Houk and Donald Hilvert and Ian A. Wilson},
  journal={Journal of molecular biology},
  year={2000},
  volume={302 5},
  pages={1213-25}
}
Antibody 21D8 catalyzes the solvent-sensitive decarboxylation of 3-carboxybenzisoxazoles. The crystal structure of chimeric Fab 21D8 with and without hapten at 1.61 A and 2.10 A, respectively, together with computational analysis, shows how a melange of polar and non-polar sites are exploited to achieve both substrate binding and acceleration of a reaction normally facilitated by purely aprotic dipolar media. The striking similarity of the decarboxylase and a series of unrelated esterase… CONTINUE READING

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