Catalysis of S-nitrosothiols formation by serum albumin: the mechanism and implication in vascular control.

@article{Rafikova2002CatalysisOS,
  title={Catalysis of S-nitrosothiols formation by serum albumin: the mechanism and implication in vascular control.},
  author={Olga Rafikova and Ruslan Rafikov and Evgeny Nudler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 9},
  pages={
          5913-8
        }
}
Nitric oxide (NO(.)) is a short-lived physiological messenger. Its various biological activities can be preserved in a more stable form of S-nitrosothiols (RS-NO). Here we demonstrate that at physiological NO(.) concentrations, plasma albumin becomes saturated with NO(.) and accelerates formation of low-molecular-weight (LMW) RS-NO in vitro and in vivo. The mechanism involves micellar catalysis of NO(.) oxidation in the albumin hydrophobic core and specific transfer of NO(+) to LMW thiols… CONTINUE READING

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