Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein.

@article{Sung1994CatalysisOA,
  title={Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein.},
  author={Patrick Sung},
  journal={Science},
  year={1994},
  volume={265 5176},
  pages={1241-3}
}
The RAD51 gene of Saccharomyces cerevisiae is required for genetic recombination and DNA double-strand break repair. Here it is demonstrated that RAD51 protein pairs circular viral single-stranded DNA from phi X 174 or M13 with its respective homologous linear double-stranded form. The product of synapsis between these DNA partners is further processed by RAD51 to yield nicked circular duplex DNA, which indicates that RAD51 can catalyze strand exchange. The pairing and strand exchange reaction… CONTINUE READING
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