Crystal Structures of a Xyloglucan Endotransglycosylase Reveal Details of Transglycosylation Acceptor Binding
- Patrik Johansson, Harry Brumer, +5 authors T. Alwyn Jonesa
- 2004
Highly Influenced
4 Excerpts
Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate
- Published 2001 in Nature
Abstract
Hen egg-white lysozyme (HEWL) was the first enzyme to have its three-dimensional structure determined by X-ray diffraction techniques. A catalytic mechanism, featuring a long-lived oxocarbenium-ion intermediate, was proposed on the basis of model-building studies. The ‘Phillips’ mechanism is widely held as the paradigm for the catalytic mechanism of… (More)