Cataloguing of Potential HIV Susceptibility Factors during the Menstrual Cycle of Pig-Tailed Macaques by Using a Systems Biology Approach

@article{Vishwanathan2015CataloguingOP,
  title={Cataloguing of Potential HIV Susceptibility Factors during the Menstrual Cycle of Pig-Tailed Macaques by Using a Systems Biology Approach},
  author={Sundaram A Vishwanathan and Adam D. Burgener and Steven E. Bosinger and Gregory K. Tharp and Patricia C. Guenthner and Nirav B. Patel and Kenzie Birse and Debra L. Hanson and Garrett Westmacott and Tara Randolph Henning and Jessica A. Radzio and Jos{\'e} Gerardo Garc{\'i}a-Lerma and T. Blake Ball and Janet M Mcnicholl and Ellen N. Kersh},
  journal={Journal of Virology},
  year={2015},
  volume={89},
  pages={9167 - 9177}
}
ABSTRACT Our earlier studies with pig-tailed macaques demonstrated various simian-human immunodeficiency virus (SHIV) susceptibilities during the menstrual cycle, likely caused by cyclic variations in immune responses in the female genital tract. There is concern that high-dose, long-lasting, injectable progestin-based contraception could mimic the high-progesterone luteal phase and predispose women to human immunodeficiency type 1 (HIV-1) acquisition and transmission. In this study, we adopted… 

Molecular Signatures of Immune Activation and Epithelial Barrier Remodeling Are Enhanced during the Luteal Phase of the Menstrual Cycle: Implications for HIV Susceptibility

A strong association between proteins involved in tissue remodeling and leukocyte infiltration with the luteal phase is indicated, which may represent potential hormone-associated mechanisms of increased susceptibility to HIV.

Factors associated with HIV susceptibility in the female genital tract

Women in HIV-serodiscordant relationships have a unique cervicovaginal environment, and that this may be associated with an altered susceptibility to HIV infection, according to Observational and experimental studies indicate that use of the injectable progestin-based contraceptive depot medroxyprogesterone acetate (DMPA) is associated with increased risk of HIV.

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It is suggested that increasing either endogenous or exogenous progestin can alter female reproductive tract barrier properties and provide plausible mechanisms for increased HIV-1 acquisition risk in the presence of increased progest in non-human primate models.

Role of Sex Hormones in Regulating Innate Immune Protection against HIV in the Human Female Reproductive Tract

The goal of this review is to summarize the multiple levels of protection against HIV infection in the FRT and thereby providing a foundation for the design of vaccines for protection against sexually-transmitted infections (STI) including HIV.

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This review focuses on the current understanding of the acute events that occur in the FGT following HIV‐1 exposure with a particular focus on the effect of endogenous and exogenous sex hormones on HIV‐ 1 susceptibility.

Sex and gender differences in HIV-1 infection.

It is discussed how a better understanding of the underlying mechanisms could improve preventive and therapeutic strategies and how oestrogen receptor signalling could represent an important mediator of sex differences in HIV-1 reservoir size and may represent a potential therapeutic target.

Characterization of the Genital Mucosa Immune Profile to Distinguish Phases of the Menstrual Cycle: Implications for HIV Susceptibility

The follicular phase of the menstrual cycle was associated with elevated level of cervical CCL2 and retention of resident memory CD4+ T cells and the impact of endogenous sexual hormones on the mucosal immune response was compared.

Animal Models of Human Viral Diseases

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