Cataloging and organizing p73 interactions in cell cycle arrest and apoptosis

@inproceedings{Tozluoglu2008CatalogingAO,
  title={Cataloging and organizing p73 interactions in cell cycle arrest and apoptosis},
  author={Melda Tozluoglu and Ezgi Karaca and Turkan Haliloglu and Ruth Nussinov},
  booktitle={Nucleic acids research},
  year={2008}
}
We have compiled the p73-mediated cell cycle arrest and apoptosis pathways. p73 is a member of the p53 family, consisting of p53, p63 and p73. p73 exists in several isoforms, presenting different domain structures. p73 functions not only as a tumor suppressor in apoptosis but also as differentiator in embryo development. p53 mutations are responsible for half of the human cancers; p73 can partially substitute mutant p53 as tumor suppressor. The pathways we assembled create a p73-centered… CONTINUE READING