Cataleptogenic effect of subtype selective 5-HT receptor antagonists in the rat.

@article{Kalkman1998CataleptogenicEO,
  title={Cataleptogenic effect of subtype selective 5-HT receptor antagonists in the rat.},
  author={Hans Otto Kalkman and V Neumann and Joachim Nozulak and Mark David Tricklebank},
  journal={European journal of pharmacology},
  year={1998},
  volume={343 2-3},
  pages={
          201-7
        }
}
Preclinical Pharmacology of FMPD [6-Fluoro-10-[3-(2-methoxyethyl)-4-methyl-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene]: A Potential Novel Antipsychotic with Lower Histamine H1 Receptor Affinity Than Olanzapine
TLDR
FMPD has the potential to have efficacy in treating schizophrenia and bipolar mania with a low risk of treatment-emergent extrapyramidal symptoms, prolactin elevation, and weight gain.
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TLDR
The data point to the existence of a bidirectional functional interaction between 5-HT1A and5-HT2A receptors, such that these receptors can support the mutual regulation of functional activity.
Clozapine-Induced Locomotor Suppression is Mediated by 5-HT2A Receptors in the Forebrain
TLDR
It is confirmed that haloperidol and risperidone caused catalepsy in rodents, driven by strong antagonism of D2, and it is shown that it is the cortical population of 5-HT2A that mediate the locomotor-suppressing effects of clozapine.
The role of α2‐adrenoceptor antagonism in the anti‐cataleptic properties of the atypical neuroleptic agent, clozapine, in the rat
TLDR
The present data strongly implicate α2‐adrenoceptor blockade in the anticataleptic properties of clozapine and suggest that its lack of extrapyramidal side effects in the clinic may also be a consequence of this property.
Interactions between neuroleptics and 5-HT1A ligands in preclinical behavioral models for antipsychotic and extrapyramidal effects
TLDR
The present data suggest that 5-HT1A agonists with intermediate or high, but not low, intrinsic activity may abolish the extrapyramidal effects of neuroleptics.
Attenuation of haloperidol‐induced catalepsy by a 5‐HT2C receptor antagonist
TLDR
The data suggest a role for 5‐HT2C receptors in the anticataleptic action of SB‐228357, and suggest that atypical neuroleptics produce fewer extrapyramidal side‐effects (EPS) than typical neurolePTics.
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References

SHOWING 1-10 OF 34 REFERENCES
Serotonergic involvement in haloperidol-induced catalepsy.
TLDR
The 5-HT receptor agonists may provide novel approaches for the development of drugs which can reverse or prevent the extrapyramidal side effects associated with antipsychotic treatment.
Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies.
TLDR
The data indicate that MDL 100,907 has a clozapine-like profile of potential antipsychotic activity with low extrapyramidal sid-effect liability.
Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.
TLDR
Preclinical data indicate that MDL 100,907 is a potent and selective ligand at the 5-HT2A receptor and selectivity as a potential antipsychotic in that it lacked consistent activity in selected rodent models of anticonvulsant, antidepressant, analgesic, or anxiolytic activity.
...
...