Catalase overexpression prevents hypertension and tubular apoptosis in angiotensinogen transgenic mice.

@article{Godin2010CatalaseOP,
  title={Catalase overexpression prevents hypertension and tubular apoptosis in angiotensinogen transgenic mice.},
  author={N. Godin and Fang Liu and Garnet J. Lau and Marie-Luise Brezniceanu and Isabelle Ch{\'e}nier and J{\'a}nos G. Filep and Julie R. Ingelfinger and Shaoling Zhang and John S. D. Chan},
  journal={Kidney international},
  year={2010},
  volume={77 12},
  pages={1086-97}
}
Transgenic mice that overexpress angiotensinogen, the sole precursor of angiotensins, in their renal proximal tubular cells develop hypertension, albuminuria, and tubular apoptosis. These pathological changes are due to enhanced generation of reactive oxygen species in the proximal tubule cells. Here, we determined whether overexpression of catalase to decrease oxidant injury in the proximal tubular cells could reverse these abnormalities. Double-transgenic mice specifically overexpressing… CONTINUE READING

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