Catalase overexpression fails to attenuate allergic airways disease in the mouse.

  title={Catalase overexpression fails to attenuate allergic airways disease in the mouse.},
  author={Niki L. Reynaert and Scott W. Aesif and Toby McGovern and Amy Brown and Emiel F. M. Wouters and Charles G. Irvin and Yvonne M. W. Janssen-Heininger},
  journal={Journal of immunology},
  volume={178 6},
Oxidative stress is a hallmark of asthma, and increased levels of oxidants are considered markers of the inflammatory process. Most studies to date addressing the role of oxidants in the etiology of asthma were based on the therapeutic administration of low m.w. antioxidants or antioxidant mimetic compounds. To directly address the function of endogenous hydrogen peroxide in the pathophysiology of allergic airway disease, we comparatively evaluated mice systemically overexpressing catalase, a… CONTINUE READING


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