Catalase mediates acetaldehyde formation in the striatum of free-moving rats.

  title={Catalase mediates acetaldehyde formation in the striatum of free-moving rats.},
  author={Mostofa Jamal and Kiyoshi Ameno and Ikuo Uekita and Mitsuru Kumihashi and Weihuan Wang and Iwao Ijiri},
  volume={28 6},
Using brain microdialysis, we measured both ethanol (EtOH) and acetaldehyde (AcH) levels in the striatum of free-moving rats following the inhibition of EtOH oxidation pathways. Rats received intraperitoneal EtOH (1g/kg) alone or in combination with 4-methylpyrazole (MP, 82 mg/kg, an alcohol dehydrogenase inhibitor), and/or catalase inhibitor sodium azide (AZ, 10mg/kg) or 3-amino-1,2,4-triazole (AT, 1g/kg), and/or cyanamide (CY, 50mg/kg, an aldehyde dehydrogenase inhibitor). Results revealed… CONTINUE READING


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