Catalase expression in delayed and premature aging mouse models.

  title={Catalase expression in delayed and premature aging mouse models.},
  author={Holly M Brown-Borg and Sharlene G. Rakoczy},
  journal={Experimental gerontology},
  volume={35 2},
The physiological decline that occurs with aging is thought to result, in part, from accumulation of oxidative damage produced by reactive oxygen species (ROS) generated during normal metabolism. Two genetic mouse models of aging, the Ames dwarf and growth hormone (GH) transgenic, suggest that hormone levels may play a role in antioxidative defense and aging. To explore this possibility, catalase (CAT), an enzyme involved in elimination of ROS, was evaluated in long-lived dwarf and short-lived… CONTINUE READING

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