Catalase enzyme mutations and their association with diseases

@article{Gth2004CatalaseEM,
  title={Catalase enzyme mutations and their association with diseases},
  author={Dr L{\'a}szl{\'o} G{\'o}th and P{\'e}ter Rass and Anik{\'o} P{\'a}y},
  journal={Molecular Diagnosis},
  year={2004},
  volume={8},
  pages={141-149}
}
Enzyme catalase seems to be the main regulator of hydrogen peroxide metabolism. Hydrogen peroxide at high concentrations is a toxic agent, while at low concentrations it appears to modulate some physiological processes such as signaling in cell proliferation, apoptosis, carbohydrate metabolism, and platelet activation. Benign catalase gene mutations of 5′ noncoding region (15) and intron 1 (4) have no effect on catalase activity and are not associated with disease. Catalase gene mutations have… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 70 references

A novel human catalase mutation Mazamdaranian and Guilanian in Iran

K Ohkura, T Miyashita, +3 authors F Kanna
Nat Biotechnol • 2003

Epidermal growth factor (EFG)-induced insulinoma (RINm) cells with improved resistance to oxidative stress. Biochem generation of hydrogen peroxide: role in EFG receptor mediated tyrosine

US Bae, SW Kang, MS Seo
Pharmacol • 2003
View 1 Excerpt

Kinetic studies on hydrogen peroxide elimina inherited catalase deficiency in human hypocatalasemic patients. Free Radic tion by cultured PC12 cells: rate limitation by glucose-5-phosphate

K Hashida, Y Sakakura, N. Makino
Biol Med • 2003
View 2 Excerpts

Acatalasemia in two Peruvian siblings . J Oral Pathol the pulmonary endothelium alleviates oxidative stress and reduces acute lung 1979 ; 8 : 35868 transplantation injury

BD Kozover, M C-Solomidou, TD Sweitzer, W Delgado, R Calderon
Biochem J • 2002

Die Katalasewirkung in normaler und carcinomatoser 92

F Blumenthal, B Rahn
The metabolic basis of inherited diseases . 4 th ed . New York : Lett • 2002

Hydrogen peroxide involved in collagen dependent superoxide dismutase gene with diabetic microangiopathy . Ter Arkh induced platelet activation

DA Chystakov, KV Savastyanov, +3 authors L Lenti
Pigment Cell Res • 2002

L-ascorbic acid induces apoptosis in acute myeloid (CAT) with vitiligo susceptibility

S Park, SS Han, CH Park
Pigment Cell Res • 2002
View 1 Excerpt

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