Catalase activity is regulated by c-Abl and Arg in the oxidative stress response.

@article{Cao2003CatalaseAI,
  title={Catalase activity is regulated by c-Abl and Arg in the oxidative stress response.},
  author={Cheng J. Cao and Yumei Leng and Donald Kufe},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 32},
  pages={29667-75}
}
The Abl family of mammalian non-receptor tyrosine kinases includes c-Abl and Arg. Recent studies have demonstrated that c-Abl and Arg are activated in the response of cells to oxidative stress. This work demonstrates that catalase, a major effector of the cellular defense against H2O2, interacts with c-Abl and Arg. The results show that H2O2 induced binding of c-Abl and Arg to catalase. The SH3 domains of c-Abl and Arg bound directly to catalase at a P293FNP site. c-Abl and Arg phosphorylated… CONTINUE READING