Catalase Overexpression Fails to Attenuate Allergic Airways Disease in the Mouse1

@article{Reynaert2007CatalaseOF,
  title={Catalase Overexpression Fails to Attenuate Allergic Airways Disease in the Mouse1},
  author={N. Reynaert and S. Aesif and T. McGovern and A. Brown and E. Wouters and C. Irvin and Y. Janssen-Heininger},
  journal={The Journal of Immunology},
  year={2007},
  volume={178},
  pages={3814 - 3821}
}
  • N. Reynaert, S. Aesif, +4 authors Y. Janssen-Heininger
  • Published 2007
  • Biology, Medicine
  • The Journal of Immunology
  • Oxidative stress is a hallmark of asthma, and increased levels of oxidants are considered markers of the inflammatory process. Most studies to date addressing the role of oxidants in the etiology of asthma were based on the therapeutic administration of low m.w. antioxidants or antioxidant mimetic compounds. To directly address the function of endogenous hydrogen peroxide in the pathophysiology of allergic airway disease, we comparatively evaluated mice systemically overexpressing catalase, a… CONTINUE READING
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