Catalase Overexpression Fails to Attenuate Allergic Airways Disease in the Mouse1

  title={Catalase Overexpression Fails to Attenuate Allergic Airways Disease in the Mouse1},
  author={N. Reynaert and S. Aesif and T. McGovern and A. Brown and E. Wouters and C. Irvin and Y. Janssen-Heininger},
  journal={The Journal of Immunology},
  pages={3814 - 3821}
  • N. Reynaert, S. Aesif, +4 authors Y. Janssen-Heininger
  • Published 2007
  • Biology, Medicine
  • The Journal of Immunology
  • Oxidative stress is a hallmark of asthma, and increased levels of oxidants are considered markers of the inflammatory process. Most studies to date addressing the role of oxidants in the etiology of asthma were based on the therapeutic administration of low m.w. antioxidants or antioxidant mimetic compounds. To directly address the function of endogenous hydrogen peroxide in the pathophysiology of allergic airway disease, we comparatively evaluated mice systemically overexpressing catalase, a… CONTINUE READING
    16 Citations
    Glutaredoxin 2 Reduces Asthma-Like Acute Airway Inflammation in Mice
    Antiinflammatory effects of hydrogen peroxide in neutrophil activation and acute lung injury.
    • 83
    Tiarellic acid attenuates airway hyperresponsiveness and inflammation in a murine model of allergic asthma.
    • 14
    Importance of oxidative stress in the pathogenesis and treatment of asthma
    • M. Riedl, A. Nel
    • Medicine
    • Current opinion in allergy and clinical immunology
    • 2008
    • 193
    The prevention of oxidative stress improve asthmatic inflammation
    • 9
    • Highly Influenced
    • PDF
    Leukocyte nicotinamide adenine dinucleotide phosphate-reduced oxidase is required for isocyanate-induced lung inflammation.
    • 8
    Catalase and glutathione peroxidase mimics.
    • B. Day
    • Medicine, Chemistry
    • Biochemical pharmacology
    • 2009
    • 173


    Reduction of antigen-induced respiratory abnormalities and airway inflammation in sensitized guinea pigs by a superoxide dismutase mimetic.
    • 60
    Nitrotyrosine Proteome Survey in Asthma Identifies Oxidative Mechanism of Catalase Inactivation1
    • 154
    • PDF
    Modulation of airway hyperresponsiveness by thiols in a murine in vivo model of allergic asthma
    • 10
    Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity.
    • 157
    • PDF
    Blockade of airway hyperresponsiveness and inflammation in a murine model of asthma by a prodrug of cysteine, L‐2‐ oxothiazolidine‐4‐carboxylic acid
    • Y. Lee, K. S. Lee, +7 authors U. Kim
    • Biology, Medicine
    • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
    • 2004
    • 73
    Extracellular glutathione peroxidase induction in asthmatic lungs: evidence for redox regulation of expression in human airway epithelial cells
    • 152
    • PDF
    Increased oxidative stress and altered levels of antioxidants in asthma.
    • 275
    Increased Oxidative Stress in Acute Exacerbations of Asthma
    • 71
    Suppression of Doxorubicin Cardiotoxicity by Overexpression of Catalase in the Heart of Transgenic Mice (*)
    • 295
    • PDF
    Nitric oxide and redox signaling in allergic airway inflammation.
    • 41