Catalase-Loaded TaOx Nanoshells as Bio-Nanoreactors Combining High-Z Element and Enzyme Delivery for Enhancing Radiotherapy.

@article{Song2016CatalaseLoadedTN,
  title={Catalase-Loaded TaOx Nanoshells as Bio-Nanoreactors Combining High-Z Element and Enzyme Delivery for Enhancing Radiotherapy.},
  author={Guosheng Song and Yuyan Chen and Chao Liang and Xuan Yi and Jingjing Liu and Xiaoqi Sun and S S Shen and Kai Yang and Zhuang Liu},
  journal={Advanced materials},
  year={2016},
  volume={28 33},
  pages={
          7143-8
        }
}
A novel type of bio-nanoreactor with catalase loaded inside TaOx hollow nanoshells is fabricated via a mild one-step method. Such bio-nanoreactors could efficiently improve the tumor oxygenation by supplying oxygen via decomposition of endogenic H2 O2 in a tumor microenvironment, and thus synergistically enhance the efficacy of cancer radiotherapy by both depositing radiation energy within the tumor and overcoming hypoxia-induced radiotherapy resistance. 
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