Catalase HPII of Escherichia coli catalyzes the conversion of protoheme to cis-heme d.

@article{Loewen1993CatalaseHO,
  title={Catalase HPII of Escherichia coli catalyzes the conversion of protoheme to cis-heme d.},
  author={Peter C Loewen and Jacek Switala and I von Ossowski and Alexander Hillar and A. W. Christie and B L Tattrie and Peter Nicholls},
  journal={Biochemistry},
  year={1993},
  volume={32 38},
  pages={10159-64}
}
Catalase HPII from aerobically grown Escherichia coli normally contains heme d but cultures grown with poor or no aeration produce HPII containing a mixture of heme d and protoheme IX. The protoheme component of HPII from anaerobically grown cells is converted into heme d during treatment of the purified enzyme with hydrogen peroxide. It is concluded that heme d found in catalase HPII is formed by the cis-hydroxylation of protoheme in a reaction catalyzed by catalase HPII using hydrogen… CONTINUE READING