Catabolism of glutathione conjugates in Arabidopsis thaliana. Role in metabolic reactivation of the herbicide safener fenclorim.

@article{BrazierHicks2008CatabolismOG,
  title={Catabolism of glutathione conjugates in Arabidopsis thaliana. Role in metabolic reactivation of the herbicide safener fenclorim.},
  author={Melissa Brazier-Hicks and Kathryn M. Evans and Oliver D Cunningham and David R. W. Hodgson and Patrick G Steel and Robert E Edwards},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 30},
  pages={21102-12}
}
The safener fenclorim (4,6-dichloro-2-phenylpyrimidine) increases tolerance to chloroacetanilide herbicides in rice by enhancing the expression of detoxifying glutathione S-transferases (GSTs). Fenclorim also enhances GSTs in Arabidopsis thaliana, and while investigating the functional significance of this induction in suspension cultures, we determined that these enzymes glutathionylated the safener. The resulting S-(fenclorim)-glutathione conjugate was sequentially processed to S-(fenclorim… CONTINUE READING
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