Catabolic Signaling and Muscle Wasting After Acute Ischemic Stroke in Mice: Indication for a Stroke-Specific Sarcopenia

@article{Springer2014CatabolicSA,
  title={Catabolic Signaling and Muscle Wasting After Acute Ischemic Stroke in Mice: Indication for a Stroke-Specific Sarcopenia},
  author={Jochen Springer and Susanne Schust and Katrin Peske and Anika Tschirner and Andre Rex and Odilo Engel and Nadja Scherbakov and Andreas Meisel and Stephan von Haehling and Michael Boschmann and Stefan D. Anker and Ulrich Dirnagl and Wolfram Doehner},
  journal={Stroke},
  year={2014},
  volume={45},
  pages={3675–3683}
}
Background and Purpose— Muscle wasting is a common complication accompanying stroke. Although it is known to impair poststroke recovery, the mechanisms of subacute catabolism after stroke have not been investigated in detail. The aim of this study is to investigate mechanisms of local and systemic catabolism and muscle wasting (sarcopenia) in a model of ischemic stroke systematically. Methods— Changes in body composition and catabolic activation in muscle tissue were studied in a mouse model of… 
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This short commentary aims to summarize recent achievements in the identification of common mechanisms leading to the skeletal muscle wasting syndrome seen in diseases as different as cancer and HD.
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It is found that there is no peripheral nerve dysfunction/degeneration as signs of a CIP-like phenotype after MCAo, and no differences in nerve conduction function nor spontaneous electromyographic activity between M CAo and sham animals.
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This study analyzes the candidate mechanisms associated with muscle atrophy in stroke patients, as well as the modulatory effect of inflammation in this condition, and suggests the two strongest anti-inflammatory candidate mechanisms, myokines and the cholinergic anti- inflammatory pathway, which may be activated by physical exercise and contribute to a decrease in proinflammatory markers of poststroke patients.
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References

SHOWING 1-10 OF 41 REFERENCES
Effect of inactivity and undernutrition after acute ischemic stroke in a rat hindlimb muscle model.
TLDR
Hindlimb muscle atrophy occurs in both affected and unaffected sides after acute stroke, with Type I muscle changes more apparent than Type II changes.
Stroke induced Sarcopenia: muscle wasting and disability after stroke.
Skeletal muscle changes after hemiparetic stroke and potential beneficial effects of exercise intervention strategies.
TLDR
New evidence reveals significant structural and metabolic changes in skeletal muscle after stroke, including gross atrophy and shift to fast myosin heavy chain in the hemiparetic leg muscle; both are related to gait deficit severity.
Prevention of liver cancer cachexia-induced cardiac wasting and heart failure.
TLDR
Systemic effects of tumours lead not only to CC but also to cardiac wasting, associated with LV-dysfunction, fibrotic remodelling, and increased mortality, which can be mitigated by treatment with either the β-blocker bisoprolol or the aldosterone antagonist spironolactone.
Elevated Tumor Necrosis Factor-&agr; in Skeletal Muscle After Stroke
TLDR
Findings demonstrate increased TNF-&agr; expression in paretic leg muscle, suggesting inflammatory pathways are accelerated in stroke muscle.
Inflammation in Acute Ischemic Stroke and its Relevance to Stroke Critical Care
TLDR
A promising novel therapeutic approach is the interleukin-1 receptor antagonist (IL-1ra), which limits the action of the cytokine IL-1, a pivotal mediator in the pathophysiology of acute neurodegeneration.
Body Weight After Stroke: Lessons From the Obesity Paradox
TLDR
An overview on the metabolic regulation in patients with stroke is presented and it is proposed that current knowledge on obesity and its management in primary prevention cannot be transferred to patients with established stroke.
Loss of Skeletal Muscle Mass after Stroke: a Systematic Review
TLDR
There is a significant difference in the regional muscle mass in the paretic vs. the nonparetic limb in individuals greater than 6-months poststroke but little is known about how early and how quickly changes in muscle mass occur.
Atrophy and impaired muscle protein synthesis during prolonged inactivity and stress.
TLDR
Prolonged inactivity and hypercortisolemia represents a persistent catabolic stimulus that exacerbates strength and lean muscle loss via a chronic reduction in muscle protein synthesis.
Endothelial Dysfunction of the Peripheral Vascular Bed in the Acute Phase after Ischemic Stroke
TLDR
The impaired vasodilator capacity of peripheral arteries reflects the TOAST classification and ADMA may play a role in ED in both acute ischemic stroke and CHF.
...
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