Casuarinin suppresses TARC/CCL17 and MDC/CCL22 production via blockade of NF-κB and STAT1 activation in HaCaT cells.

@article{Kwon2012CasuarininST,
  title={Casuarinin suppresses TARC/CCL17 and MDC/CCL22 production via blockade of NF-κB and STAT1 activation in HaCaT cells.},
  author={Dong-Joo Kwon and Young-Soo Bae and Sung Mi Ju and Ah Ra Goh and Gi Soo Youn and Soo Young Choi and Jae-Bong Park},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={417 4},
  pages={1254-9}
}
Casuarinin is a naturally occurring tannin that is isolated from the leaves of Hippophae rhamnoides. It has been shown to have anti-oxidant, anti-cancer, anti-viral, and anti-inflammatory activities. The aim of this study was to investigate the possible mechanism by which casuarinin inhibits TNF-α/IFN-γ-induced Th2 chemokines expression in the human keratinocytes cell line HaCaT. We found that casuarinin suppressed TNF-α/IFN-γ-induced expression of TARC and MDC mRNA and protein in HaCaT cells… CONTINUE READING