Castration-resistant prostate cancer: locking up the molecular escape routes.

  title={Castration-resistant prostate cancer: locking up the molecular escape routes.},
  author={R. Attar and Chris H M Takimoto and Marco M. Gottardis},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={15 10},
The understanding of the key role that androgens play on the normal and pathological physiology of the prostate guided the development of different therapies for the treatment of locally advanced or metastatic prostate cancer (PCa). These so-called androgen deprivation therapies include surgical or chemical castration, achieved by the administration of gonadotropin-releasing hormone analogs; inhibition of steroidogenic enzymes; and finally, blocking of the binding of androgens to their receptor… CONTINUE READING