Castration reduces motoneuron soma size but not dendritic length in the spinal nucleus of the bulbocavernosus of wild-type and BCL-2 overexpressing mice.

@article{Park2002CastrationRM,
  title={Castration reduces motoneuron soma size but not dendritic length in the spinal nucleus of the bulbocavernosus of wild-type and BCL-2 overexpressing mice.},
  author={John W Park and Susan L. Zup and Tom Verhovshek and Dale Robert Sengelaub and N G Forger},
  journal={Journal of neurobiology},
  year={2002},
  volume={53 3},
  pages={403-12}
}
Motoneurons in the spinal nucleus of the bulbocavernosus (SNB) and their target muscles, bulbocavernosus and levator ani (BC/LA), constitute an androgen-sensitive neuromuscular system. Testosterone regulates SNB soma size, SNB dendritic length, and BC/LA muscle mass in adult male rats. Recent evidence indicates that the cell death-regulatory protein, Bcl-2, may also play a role in adult neural plasticity. The present study examined whether gonadal hormones and/or the Bcl-2 protein influence the… CONTINUE READING

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Overexpression of bcl-2 reduces sex differences in neuron number in the brain and spinal cord.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2003
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