Casticin induces growth suppression and cell cycle arrest through activation of FOXO3a in hepatocellular carcinoma.

@article{He2013CasticinIG,
  title={Casticin induces growth suppression and cell cycle arrest through activation of FOXO3a in hepatocellular carcinoma.},
  author={Lihua He and Xiaohong Yang and Xiaocheng Cao and Fei Liu and Meifang Quan and Jianguo Cao},
  journal={Oncology reports},
  year={2013},
  volume={29 1},
  pages={103-8}
}
Casticin, a polymethoxyflavone, has been reported to exert anticancer activities. The objectives of this study were to examine the molecular mechanisms by which casticin induces the growth inhibition and cell cycle arrest in human hepatocellular carcinoma (HCC) cells. The HCC cell lines Hep G2 and PLC/PRF/5 were cultured in vitro. The growth inhibitory effects of casticin were evaluated using clonogenic assays. The distribution of… CONTINUE READING

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