Castalagin from Anogeissus leiocarpus mediates the killing of Leishmania in vitro

  title={Castalagin from Anogeissus leiocarpus mediates the killing of Leishmania in vitro},
  author={Mohammed Nasir Shuaibu and Kiran Pandey and Ponchang Apollos Wuyep and Tetsuo Yanagi and Kenji Hirayama and Akitoyo Ichinose and T. Tanaka and Isao Kouno},
  journal={Parasitology Research},
Stem barks of Anogeissus leiocarpus and Terminalia avicennoides widely used in Africa for treatment of some parasitic diseases were collected and made into methanolic extracts. The extracts were tested on four strains of promastigote forms of Leishmania in vitro. Solvent fractionation in aqueous, butanolic, and ethyl acetate layer indicated butanol and aqueous fractions to have a superior leishmanicidal activity. Chromatographic separation of the butanolic fraction on Sephadex LH-20 followed by… 

Anti-plasmodial Activity of the Mixed Stem Bark Extracts of Anogeissus leiocarpus and Prosopis africana and in vitro Evaluation of Its Tablet Dosage Form

The antinociceptive, immunostimulatory, and antiplasmodial properties of Anogeissus leiocarpus and Prosopis africana combined aqueous extract and its single tablet formulation were evaluated, proving to be suitable in acute malaria attack.

Potential Anti-Tuberculosis Activity of the Extracts and Their Active Components of Anogeissus leiocarpa (DC.) Guill. and Perr. with Special Emphasis on Polyphenols

The antimycobacterial results obtained from this research justify the use of A. leiocarpa in Sudanese folk medicine against cough related to TB and sources for new potent anti-TB drug lead compounds.

Anthelmintic Activity of Punicalagin from nogeissus Leiocarpus

The presence of punicalagin isomers (α & β) and its galloyl ester, 1-O-galloyl-punicalagin as major components in the leaf extract of A. leiocarpus was documents, indicating that other compounds present in the extract may have also contributed to the activity.


The presented review summarizes the information concerning the botany, constituents, traditional uses, biological activity and toxicity of the plant.

Effect of Methanolic Extract of Stem Bark of Anogeissus Leiocarpus on Liver Function of Mice Infected with Plasmodium Berghei

Treatment of malaria with A. leiocarpus in doses higher than 200−1 body weight must be carefully monitored to avoid liver toxicity.


The stem-bark of Anogeissusleiocarpus contains phytochemicals that have potentials to be developed into antimicrobial drugs useful for the treatment of diseases caused by those microorganisms the plant indicated activity against it.

Cytotoxic Screening and In Vitro Evaluation of Pentadecane Against Leishmania infantum Promastigotes and Amastigotes

In vitro effects of pentadecane in Leishmania infantum parasites are investigated and it is found that it decreases growth by 86 ± 2% both in promastigotes and in amastigote, resulting in a reduction of macrophage infection.

Inhibitory and Reversal Effects of Extracts and Fractions of Anogeissus leiocarpa (DC.) Guill. & Perr. on Sodium Metabisulphite– induced Polymerization of Sickle Cell Haemoglobin

The leaves and stem bark of Anogeissus leiocarpa (DC.) Guill. & Pirr. (Combretaceae) are commonly included in recipes used for the management of sickle cell disease in western part of Nigeria.

Antiplasmodial Activity of Methanolic Leaf Extract of Anogeisus Leiocarpus and its Effect on Heart and Liver of Mice Infected with Plasmodium Berghei

This study shows that the antiplasmodial activity of A. leiocarpus was higher at the dosage of 200 mg/kgbdw and the level of liver enzymes is a function of the dosage.



Trypanocidal activity of extracts and compounds from the stem bark of Anogeissus leiocarpus and Terminalia avicennoides

Effect of the compounds on fibroblasts did not reveal serious toxicity at moderate concentration but is concentration dependent, and hydrolysable tannins with a range of activity were revealed.

In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle

Findings are the first report of hydrolysable tannins exhibiting antitrypanosomal and antiplasmodial activities of the Ethiopian medicinal plant Combretum molle.

Induction of apoptosis by hydrolyzable tannins from Eugenia jambos L. on human leukemia cells.

Antiproliferative constituents in the plant 8. Seeds of Rhynchosia volubilis.

The MeOH extract of the seeds of Rhynchosia volubilis (Leguminosae) showed antiproliferative activity against human gastric adenocarcinoma, human uterus carcinoma, and murine melanoma cells.

Natural products as trypanocidal, antileishmanial and antimalarial drugs.

This review covers recent studies on plant-secondary metabolites isolated from medicinal plants that have demonstrated moderate to high activity in in vitro and in vivo bioassays against these protozoa.

Pentostam induces resistance to antimony and the preservative chlorocresol in Leishmania donovani promastigotes and axenically grown amastigotes

Data show that resistance to Pentostam induced in antimony-insensitive promastigotes is manifested in amastigote as resistance both to pentavalent antimony and to chlorocresol.

Medicinal plants in the fight against Leishmaniasis

  • H. K. Majumdar
  • Chemistry, Biology
    Indian Journal of Clinical Biochemistry
  • 2008
Some synthetic and natural compounds, inhibitory effects of these synthetic compounds indolyl quinolines and plant derived compound amarogentin, an iridoid glycoside on DNA topoisomerases Leishmania were investigated and the results will be discussed from.

Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years.

  • J. Berman
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1997
The current interest in leishmaniasis stems from the importance of this disease with respect to travel medicine, veterans of Operation Desert Storm, humanitarian concerns, and infection with human

Recent advances in the fight against leishmaniasis with natural products.

Natural compounds with antileishmanial activity are coumarins, chalcones, lactones, tetralones and saponins, some of them are known antiprotozoal natural products.

New medicines from nature's armamentarium.

  • A. Crump
  • Medicine
    Trends in parasitology
  • 2006