Castalagin from Anogeissus leiocarpus mediates the killing of Leishmania in vitro

@article{Shuaibu2008CastalaginFA,
  title={Castalagin from Anogeissus leiocarpus mediates the killing of Leishmania in vitro},
  author={Mohammed Nasir Shuaibu and Kiran Pandey and Ponchang Apollos Wuyep and Tetsuo Yanagi and Kenji Hirayama and Akitoyo Ichinose and T. Tanaka and Isao Kouno},
  journal={Parasitology Research},
  year={2008},
  volume={103},
  pages={1333-1338}
}
Stem barks of Anogeissus leiocarpus and Terminalia avicennoides widely used in Africa for treatment of some parasitic diseases were collected and made into methanolic extracts. The extracts were tested on four strains of promastigote forms of Leishmania in vitro. Solvent fractionation in aqueous, butanolic, and ethyl acetate layer indicated butanol and aqueous fractions to have a superior leishmanicidal activity. Chromatographic separation of the butanolic fraction on Sephadex LH-20 followed by… 

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