Cassava haplotype map highlights fixation of deleterious mutations during clonal propagation

@article{Ramu2017CassavaHM,
  title={Cassava haplotype map highlights fixation of deleterious mutations during clonal propagation},
  author={Punna Ramu and Williams Esuma and Robert Kawuki and Ismail Y. Rabbi and Chiedozie Egesi and Jessen V. Bredeson and Rebecca S Bart and Janu Verma and Edward S. Buckler and Fei Lu},
  journal={Nature Genetics},
  year={2017},
  volume={49},
  pages={959-963}
}
Cassava (Manihot esculenta Crantz) is an important staple food crop in Africa and South America; however, ubiquitous deleterious mutations may severely decrease its fitness. To evaluate these deleterious mutations, we constructed a cassava haplotype map through deep sequencing 241 diverse accessions and identified >28 million segregating variants. We found that (i) although domestication has modified starch and ketone metabolism pathways to allow for human consumption, the concomitant… CONTINUE READING
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