Caspr2, a New Member of the Neurexin Superfamily, Is Localized at the Juxtaparanodes of Myelinated Axons and Associates with K+ Channels

@article{Poliak1999Caspr2AN,
  title={Caspr2, a New Member of the Neurexin Superfamily, Is Localized at the Juxtaparanodes of Myelinated Axons and Associates with K+ Channels},
  author={Sebastian Poliak and Leora Gollan and Ricardo Mart{\'i}nez and Andrew W Custer and Steven Einheber and James L. Salzer and James S Trimmer and Peter G Shrager and Elior Peles},
  journal={Neuron},
  year={1999},
  volume={24},
  pages={1037-1047}
}
Rapid conduction in myelinated axons depends on the generation of specialized subcellular domains to which different sets of ion channels are localized. Here, we describe the identification of Caspr2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), and show that this neurexin-like protein and the closely related molecule Caspr/Paranodin demarcate distinct subdomains in myelinated axons. While contactin-associated protein (Caspr) is present at the paranodal junctions, Caspr2 is precisely… CONTINUE READING
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