Caspofungin activity against clinical isolates of fluconazole-resistant Candida.

  title={Caspofungin activity against clinical isolates of fluconazole-resistant Candida.},
  author={Michael A. Pfaller and Shawn A. Messer and Linda B Boyken and Cassie L Rice and Shailesh Tendolkar and Richard J. Hollis and Daniel J. Diekema},
  journal={Journal of clinical microbiology},
  volume={41 12},
A total of 7,837 clinical isolates of Candida were tested against fluconazole, and 351 resistant (fluconazole MIC >/=64 micro g/ml) isolates were identified (4% of the total tested). All fluconazole-resistant isolates were inhibited by caspofungin at concentrations that can be exceeded by standard doses (MIC at which 90% of the isolates were inhibited, 1 micro g/ml; 99% of the MICs were </=2 micro g/ml). 

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