Caspases in cell survival, proliferation and differentiation

  title={Caspases in cell survival, proliferation and differentiation},
  author={Mohamed Lamkanfi and Nele Festjens and Wim Declercq and Tom Vanden Berghe and Peter Vandenabeele},
  journal={Cell Death and Differentiation},
Caspases, a family of evolutionarily, conserved cysteinyl proteases, mediate both apoptosis and inflammation through aspartate-specific cleavage of a wide number of cellular substrates. Most substrates of apoptotic caspases have been conotated with cellular dismantling, while inflammatory caspases mediate the proteolytic activation of inflammatory cytokines. Through detailed functional analysis of conditional caspase-deficient mice or derived cells, caspase biology has been extended to cellular… CONTINUE READING
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