Caspases: the executioners of apoptosis.

  title={Caspases: the executioners of apoptosis.},
  author={G. M. Cohen},
  journal={The Biochemical journal},
  volume={326 ( Pt 1)},
Apoptosis is a major form of cell death, characterized initially by a series of stereotypic morphological changes. In the nematode Caenorhabditis elegans, the gene ced-3 encodes a protein required for developmental cell death. Since the recognition that CED-3 has sequence identity with the mammalian cysteine protease interleukin-1 beta-converting enzyme (ICE), a family of at least 10 related cysteine proteases has been identified. These proteins are characterized by almost absolute specificity… CONTINUE READING
Highly Influential
This paper has highly influenced 63 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
1,445 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 1,445 extracted citations

Similar Papers

Loading similar papers…