Caspase substrates and cellular remodeling.

  title={Caspase substrates and cellular remodeling.},
  author={Emily D Crawford and James A. Wells},
  journal={Annual review of biochemistry},
The caspases are unique proteases that mediate the major morphological changes of apoptosis and various other cellular remodeling processes. As we catalog and study the myriad proteins subject to cleavage by caspases, we are beginning to appreciate the full functional repertoire of these enzymes. Here, we examine current knowledge about caspase cleavages: what kinds of proteins are cut, in what contexts, and to what end. After reviewing basic caspase biology, we describe the technologies that… CONTINUE READING
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