Caspase-specific and nonspecific in vivo protein processing during Fas-induced apoptosis

@article{Damme2005CaspasespecificAN,
  title={Caspase-specific and nonspecific in vivo protein processing during Fas-induced apoptosis},
  author={Petra Van Damme and Lennart Martens and Jozef van Damme and Koen Hugelier and An Staes and Jo{\"e}l Vandekerckhove and Kris Gevaert},
  journal={Nature Methods},
  year={2005},
  volume={2},
  pages={771-777}
}
We generated a comprehensive picture of protease substrates in anti-Fas–treated apoptotic human Jurkat T lymphocytes. We used combined fractional diagonal chromatography (COFRADIC) sorting of protein amino-terminal peptides coupled to oxygen-16 or oxygen-18 differential labeling. We identified protease substrates and located the exact cleavage sites within processed proteins. Our analysis yielded 1,834 protein identifications and located 93 cleavage sites in 71 proteins. Indirect evidence of… CONTINUE READING
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