Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis

@article{Zhang1999CaspasemediatedCO,
  title={Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis},
  author={Yongke Zhang and Naoya Fujita and Takashi Tsuruo},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={1131-1138}
}
The cyclin-dependent kinase inhibitor p21Waf1/Cip1 is a downstream effector of the p53-dependent cell growth arrest. We report herein that p21 was cleaved by caspase-3/CPP32 at the site of DHVD112↓L during the DNA damage-induced apoptosis of cancer cells. The cleaved p21 fragment could no more arrest the cells in G1 phase nor suppress the cells undergoing apoptosis because it failed to bind to the proliferating cell nuclear antigen (PCNA) and lost its capability to localize in the nucleus. Thus… CONTINUE READING