Caspase inhibitors promote vestibular hair cell survival and function after aminoglycoside treatment in vivo.

@article{Matsui2003CaspaseIP,
  title={Caspase inhibitors promote vestibular hair cell survival and function after aminoglycoside treatment in vivo.},
  author={Jonathan Isamu Matsui and Asim E. Haque and David Huss and Elizabeth P Messana and Julie A. Alosi and David W Roberson and Douglas Allen Cotanche and J. David Dickman and Mark E. Warchol},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 14},
  pages={6111-22}
}
The sensory hair cells of the inner ear undergo apoptosis after acoustic trauma or aminoglycoside antibiotic treatment, causing permanent auditory and vestibular deficits in humans. Previous studies have demonstrated a role for caspase activation in hair cell death and ototoxic injury that can be reduced by concurrent treatment with caspase inhibitors in vitro. In this study, we examined the protective effects of caspase inhibition on hair cell death in vivo after systemic injections of… CONTINUE READING