Caspase inhibitors promote alternative cell death pathways.

  title={Caspase inhibitors promote alternative cell death pathways.},
  author={Peter Vandenabeele and Tom Vanden Berghe and Nele Festjens},
  journal={Science's STKE : signal transduction knowledge environment},
  volume={2006 358},
The use of caspase inhibitors has revealed the existence of alternative backup cell death programs for apoptosis. The broad-spectrum caspase inhibitor zVAD-fmk modulates the three major types of cell death. Addition of zVAD-fmk blocks apoptotic cell death, sensitizes cells to necrotic cell death, and induces autophagic cell death. Several studies have shown a crucial role for the kinase RIP1 and the adenosine nucleotide translocator (ANT)-cyclophilin D (CypD) complex in necrotic cell death. The… CONTINUE READING