Caspase-independent component of retinal ganglion cell death, in vitro.

  title={Caspase-independent component of retinal ganglion cell death, in vitro.},
  author={G{\"u}lg{\"u}n Tezel and Xiangjun Yang},
  journal={Investigative ophthalmology & visual science},
  volume={45 11},
PURPOSE Although in vitro and in vivo models demonstrate caspase activation in retinal ganglion cells (RGCs) undergoing apoptosis, the caspase-independent component of RGC death is unclear. Identification of the precise mechanisms of cell death in these distinct neurons is essential for the development of effective neuroprotective strategies in glaucoma. Because TNF-alpha and hypoxia have been implicated in RGC death during glaucomatous optic nerve degeneration, this study was conducted to… CONTINUE READING


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