Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis.

@article{Carter2003CaspaseindependentCD,
  title={Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis.},
  author={Bing Z. Carter and Steven M. Kornblau and Twee Tsao and Rui-yu Wang and Wendy D. Schober and Michele Milella and Hsi-Guang Sung and John C. Reed and Michael Andreeff},
  journal={Blood},
  year={2003},
  volume={102 12},
  pages={4179-86}
}
Survivin and XIAP, members of the protein family known as the inhibitors of apoptosis, interfere with the activation of caspases, called the "cell death executioners." We examined Survivin (n = 116) and XIAP (n = 172) expression in primary acute myeloid leukemia (AML) blasts and assessed the impact of their expression on prognosis. They were detected in all samples analyzed. However, no correlation was observed with cytogenetics, remission attainment, or overall survival of patients with AML… CONTINUE READING

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Pleiotropic cell-division defects and apoptosis induced by APOPTOSIS IN AML 4185 BLOOD

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