• DOI:10.1038/nm1263
Corpus ID: 8264709

Caspase-independent cell death

@article{Kroemer2005CaspaseindependentCD,
  title={Caspase-independent cell death},
  author={G. Kroemer and S. Martin},
  journal={Nature Medicine},
  year={2005},
  volume={11},
  pages={725-730}
}

G. Kroemer, S. Martin

Published 2005

Biology, Medicine

Nature Medicine

Caspase activation has been frequently viewed as synonymous with apoptotic cell death; however, caspases can also contribute to processes that do not culminate in cell demise. Moreover, inhibition of caspases can have cytoprotective effects. In a number of different models, caspase inhibition does not maintain cellular viability and instead shifts the morphology of death from apoptosis to nonapoptotic pathways. Here, we explore the contribution of caspases to cell death, either as upstream… CONTINUE READING

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