Caspase-independent cell death

  title={Caspase-independent cell death},
  author={G. Kroemer and S. Martin},
  journal={Nature Medicine},
  • G. Kroemer, S. Martin
  • Published 2005
  • Biology, Medicine
  • Nature Medicine
  • Caspase activation has been frequently viewed as synonymous with apoptotic cell death; however, caspases can also contribute to processes that do not culminate in cell demise. Moreover, inhibition of caspases can have cytoprotective effects. In a number of different models, caspase inhibition does not maintain cellular viability and instead shifts the morphology of death from apoptosis to nonapoptotic pathways. Here, we explore the contribution of caspases to cell death, either as upstream… CONTINUE READING
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