Caspase-independent apoptosis, in human MCF-7c3 breast cancer cells, following photodynamic therapy, with a novel water-soluble phthalocyanine.

@article{Vittar2010CaspaseindependentAI,
  title={Caspase-independent apoptosis, in human MCF-7c3 breast cancer cells, following photodynamic therapy, with a novel water-soluble phthalocyanine.},
  author={Natalia Bel{\'e}n Rumie Vittar and Josefina Awruch and Kashif Azizuddin and Viviana Alicia Rivarola},
  journal={The international journal of biochemistry & cell biology},
  year={2010},
  volume={42 7},
  pages={
          1123-31
        }
}
A new water-soluble phthalocyanine derivative, 2,3,9,10,16,17,23,24-octakis(3-aminopropyloxy) phthalocyaninato zinc II (PoII) was studied as a photosensitizer for photodynamic therapy (PDT) in MCF-7c3 cells. We report here that PoII and red light induces apoptosis. However, the precise mechanism appears to differ from that induced by PDT with other known phthalocyanines. The present study provides evidence that in the case of PoII, caspases do not participate in the apoptotic response. PoII-PDT… CONTINUE READING
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